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目的观察分析孕妇血清IgG抗A(B)效价、妊娠次数及年龄因素与新生儿溶血病的相关性。方法检测母婴血型不合孕妇血清IgG抗A(B)效价,分别统计不同IgG抗A(B)效价的孕产妇中发生因ABO血型不合所致的新生儿溶血病的比率,并比较不同妊娠次数、不同年龄段的孕妇发生新生儿溶血的比率。结果孕妇不同血清IgG抗A(B)效价时、不同妊娠次数时及孕妇的不同年龄段时发生新生儿ABO溶血病的比率之间均有统计学差异(P<0.05),随着孕妇血清IgG抗A(B)效价的增高、妊娠次数的增加及孕妇年龄的增加,新生儿ABO溶血病的发病也增多。结论为保障母婴安全,减少新生儿溶血病的发生率,有条件时检测孕妇血清IgG抗A(B)效价,并尽量减少妊娠次数及避免高龄怀孕。
Objective To observe and analyze the relationship between serum IgG anti-A (B) titer, number of pregnancies and age factors and hemolytic disease of newborn in pregnant women. Methods The serum IgG anti-A (B) titers in maternal and neonatal non-pregnant women were measured. The rates of neonatal hemolytic disease due to incompatible ABO blood group were calculated in maternal with different IgG anti-A (B) The number of pregnancies, the incidence of neonatal hemolysis in pregnant women of different ages. Results There was a significant difference (P <0.05) in the rates of IgG anti-A (B) serum of different pregnant women, ABO hemolytic disease rate in different pregnancy times and different age groups of pregnant women (P <0.05) Increased IgG anti-A (B) titer, increased number of pregnancies, and increased age of pregnant women have also increased the incidence of ABO hemolytic disease in newborns. Conclusion In order to ensure the safety of mother and infant and reduce the incidence of hemolytic disease in newborn, serum IgG anti-A (B) titer of pregnant women should be tested when possible, and the number of pregnancy should be minimized and the elderly pregnant should be avoided.