Analysis of anti-zona pellucida antibody and tumor necrosis factor-α,γ-interferon and interleukin-2

• 作 者: 王一峰 韩兰英 欧汝强 杨宁 谢端薇 陈巧儿
• 机 构: Family Planning Research Institute of Guangdong
• 出 处: 生殖医学杂志
• 发表日期: 2004年期
• 关键词: Premature ovarian failure Anti-zona pellucida antibody Tumornecrosis factor-α In

Objective:To investigate the role and the clinical significance of anti-zona pellucidaantibody (AzpAb) and tumor necrosis factor-α(TNF-α),γ-interferon(IFN-γ) and inter-leukin-2 (IL-2) in sera from patients with premature ovarian failure (POF).Methods: The AzpAb in the serum of POF patient was analyzed by means ofELISA. The levels of TNF-α, IL-2 and IFN-γ in the serum were determined by meansof radioimmunoassay (RIA).Results:The level of serum AzpAb in the POF patients was significantly higher thanthat of the normal controls(P＜0.001). The levels of TNF-α and IL-2 were significantlyreduced (P＜0. 001), and the level of IFN-γ was significantly elevated (P＜0.01). Thelevels of above three cytokines in AzpAb positive group were significantly higher thanthose of the negative group in POF patients.Conclusion: This study suggested that AzpAb, TNF-α, IFN-γ and IL-2 might playimportant roles in the pathogenesis of autoimmune POF.