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目的:观察2型糖尿病维吾尔医不同体液证型患者胰岛素抵抗、胰岛β细胞功能有关指标的变化,探讨各体液证型与胰岛素抵抗、胰岛β细胞功能状况的关系。方法:随机选取住院治疗的131例2型糖尿病患者,按维医理论进行分型,观察空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)并采用稳态模型评估法胰岛素抵抗指数(HOMA-IR)评价胰岛素抵抗,胰岛β细胞功能指数(HOMA-β)及△I30/△G30分别评价基础状态下及糖负荷后早期胰岛β细胞功能,并对其进行分析。结果:异常黑胆质型2型糖尿病的构成比为48.09%,几乎与其它3种维医异常体液类型2型糖尿病的总和相当。异常黑胆质型2型糖尿病组FPG明显高于异常血液质型及异常胆液质型2型糖尿病组(P<0.05),异常黑胆质型2型糖尿病组2hPG及HbA1c明显高于其他3组维医异常体液类型2型糖尿病组(P<0.05);异常黑胆质型2型糖尿病组HOMA-IR明显高于异常血液质型及异常胆液质型2型糖尿病组(P<0.05)。异常黑胆质型2型糖尿病组HOMA-β明显低于其他3种维医异常体液类型2型糖尿病组(P<0.05);异常黑胆质型2型糖尿病负荷后早期胰岛素分泌(△I30/△G30)明显低于异常血液质型、异常胆液质型及异常黏液质型2型糖尿病组(P<0.05)。结论:异常黑胆质型2型糖尿病是2型糖尿病维医体液分型的主要证型。与其他3种维医异常体液类型2型糖尿病比较,异常黑胆质型2型糖尿病患者的糖代谢紊乱状况更明显,胰岛素抵抗及胰岛β细胞功能受损更为严重。
Objective: To observe the changes of insulin resistance and pancreatic β-cell function in patients with type 2 diabetes mellitus with different body fluid syndromes, and to explore the relationship between the syndromes of body fluid and insulin resistance and the function of pancreatic β cells. Methods: A total of 131 patients with type 2 diabetes mellitus who were hospitalized were selected randomly and classified according to the theory of traditional Chinese medicine. Fasting plasma glucose (FPG), postprandial 2h blood glucose (HbA1c), and HbA1c were observed. Insulin The insulin resistance, HOMA-β and △ I30 / △ G30 were evaluated by HOMA-IR, and the function of early-stage islet β-cells after basal and glucose loading were evaluated respectively. Results: The ratio of abnormal Savda type 2 diabetes mellitus was 48.09%, which was almost the same as the sum of the other three types of abnormal body fluid type 2 diabetes mellitus. The FPG in patients with abnormal savda type 2 diabetes mellitus was significantly higher than those in patients with abnormal blood type and abnormal bile-type type 2 diabetes (P <0.05), and 2hPG and HbA1c in patients with abnormal savda type 2 diabetes mellitus were significantly higher than those in other 3 HOMA-IR in abnormal savda type 2 diabetes group was significantly higher than that in abnormal blood group and abnormal bile-type type 2 diabetes group (P <0.05) . HOMA-β in abnormal savda type 2 diabetes mellitus group was significantly lower than those in the other three types of abnormal body fluid type 2 diabetes mellitus (P <0.05); early abnormal insulin secretion in abnormal savda type 2 diabetes mellitus (△ I30 / △ G30) was significantly lower than those in abnormal blood group, abnormal bile duct type and abnormal mucinous type 2 diabetes group (P <0.05). Conclusions: Aberrant savda type 2 diabetes is the main syndrome type of type 2 diabetes mellitus. Compared with the other three types of abnormal body fluids type 2 diabetes mellitus, abnormal savda type 2 diabetes patients with glucose metabolism disorder is more obvious, insulin resistance and pancreatic β-cell function is more serious damage.