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目的:研究拟黑多翅蚁醇提物、水提物抗痛风作用。方法:昆明种小鼠、Wistar大鼠各90只,设正常对照组、模型组、阳性对照组及给药组(按生药量计为4,2,1 g.kg-1),ig给药,给药15 d,末次给药后,小鼠ip次黄嘌呤复制高尿酸血症模型,观察拟黑多翅蚁醇提物、水提物对高尿酸血症及正常小鼠尿酸水平的影响;大鼠足跖注射微晶型尿酸钠结晶,复制痛风性炎症模型,观察拟黑多翅蚁醇提物、水提物对痛风性炎症的影响。结果:正常对照组血清尿酸(131.09±45.78)μmol.L-1,模型组血清尿酸(198.63±47.27)μmol.L-1,与模型组比较,拟黑多翅蚁醇提物(4,2 g.kg-1)、水提物(4 g.kg-1)可以显著降低高尿酸血症小鼠的血尿酸水平(P<0.05),对正常小鼠血尿酸水平无显著影响;拟黑多翅蚁醇提物、水提物可显著抑制微晶型尿酸钠引起大鼠足跖肿胀,致炎后1～3 h肿胀较模型组有显著降低(P<0.05,P<0.01)。拟黑多翅蚁醇提物的药效略优于水提物。结论:拟黑多翅蚁有降低痛风模型血清尿酸水平及抗炎作用。
OBJECTIVE: To study the anti-gout effect of alcohol extract and water extract of Polyastrus striatum. Methods: Ninety Kunming mice and 90 Wistar rats were divided into normal control group, model group, positive control group and administration group (4,2,1 g.kg-1) , For 15 days. After the last administration, the model of hyperuricemia was induced by ip injection of hypoxanthine in mice. The effects of ethanol extracts of aqueous extract of Polygonatum militaris on hyperuricemia and uric acid levels in normal mice were observed The rats were injected with microcrystalline sodium urate into their plantar cells to replicate the model of gout inflammation. The effects of ethanol extract and water extract on gouty inflammation were observed. Results: Serum uric acid (131.09 ± 45.78) μmol.L-1 in normal control group and serum uric acid (198.63 ± 47.27) μmol.L-1 in model group were significantly lower than those in model group g.kg-1) and water extract (4 g.kg-1) could significantly reduce the level of serum uric acid in hyperuricemic mice (P <0.05), and had no significant effect on the level of serum uric acid in normal mice. The polytrichin alcohol extract and water extract could significantly inhibit the rat paw edema induced by microcrystalline sodium urate. The swelling in 1-3 h after inflammation was significantly lower than that in the model group (P <0.05, P <0.01). The potency of the alcohol extract of Prophetodes pseudotalis is slightly better than that of water extract. Conclusion: The polyaspus ants reduce serum uric acid level and anti-inflammatory effects of gout model.