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作者测定了１１７例鼻咽癌患者外周血ＮＫ细胞活性水平，并与４０例健康者进行比较，结果发现鼻咽癌患者外周血ＮＫ细胞活性低于对照组（Ｐ＜０．０１），低分化鳞状细胞癌、未分化细胞癌患者ＮＫ细胞活性显著低于中分化鳞状细胞癌和对照组（Ｐ＜０．０５和Ｐ＜０．０１）；ＵＩＣＣ－ＴＮＭ分期Ⅱ、Ⅲ、Ⅳ期和复发病例的ＮＫ细胞活性均数各为２５．７５±１４．６３、２４．７０±１２．４２、１９．１５±８．２９、１５．６５±７．２５，Ⅳ期和复发者显著低于Ⅱ、Ⅲ期者（Ｐ＜０．０５）。血ＮＫ细胞活性与鼻咽癌患者血清ＥＢ病毒ＶＣＡ－ＩｇＡ抗体水平呈负相关（γｓ＝－０．８５，Ｐ＜０．０５）。结果表明鼻咽癌患者外周血ＮＫ细胞活性受抑制，并随病情进展而下降。作者认为检测外周血ＮＫ细胞活性可作为评估鼻咽癌预后的一项辅助指标。
The authors measured the activity of NK cells in peripheral blood of 117 patients with nasopharyngeal carcinoma and compared with 40 healthy controls. The results showed that the NK cell activity in peripheral blood of patients with nasopharyngeal carcinoma was lower than that of the control group (P <0.01) The activity of NK cells in squamous cell carcinoma and undifferentiated cell carcinoma was significantly lower than that in moderately differentiated squamous cell carcinoma and the control group (P <0.05 and P <0.01). UICC-TNM stage Ⅱ, Ⅲ, Ⅳ and The recurrence of NK cell activity were 25.75 ± 14.63,24.70 ± 12.42,19.15 ± 8.29,15.65 ± 7.25, Ⅳ and recurrence were significantly lower than Ⅱ, Ⅲ period (P <0.05). Blood NK cell activity was negatively correlated with serum Epstein-Barr virus (VCA-IgA) antibody levels in patients with nasopharyngeal carcinoma (γs = -0.85, P <0.05). The results showed that NK cell activity in peripheral blood of patients with nasopharyngeal carcinoma was inhibited and decreased with the progression of the disease. The authors believe that the detection of peripheral blood NK cell activity can be used as a prognostic assessment of nasopharyngeal carcinoma as a secondary indicator.