Inter-chain disulfide bond improved protein trans-splicing increases plasma coagulation activity in

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：zcb737

【摘要】

：

Protein trans-splicing based dual-vector factor VIII(FVIII) gene delivery is adversely affected by less efficiency of protein splicing.We sought to increase the

【作者】

：

ZHU FuXiang LIU ZeLong WANG Xi

【机构】

：

CollegeofLifeScience,DepartmentofHematology

【出处】

：

中国科学：生命科学英文版

【发表日期】

：

2013年3期

【关键词】

：

高蛋白质反式剪接凝血活性 I基因二硫键门静脉轻链小鼠 coagulation factor VIII protein trans-splicing

【基金项目】

：

supported by the Natural Science Foundation of Shandong Province (ZR2010CM061),the Scientific Research Foundation from Ministry of Education for Returned Overseas Chinese Scholars (20071108)

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Protein trans-splicing based dual-vector factor VIII(FVIII) gene delivery is adversely affected by less efficiency of protein splicing.We sought to increase the amount of spliced FVIII protein and plasma coagulation activity in dual-vector FVIII transgene

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Inter-chain disulfide bond improved protein trans-splicing increases plasma coagulation activity in

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