血清总唾液酸在食管癌早诊中的研究

• 作 者: 李琰 段建平 孙玉敏 郭翠兰 乔翠云
• 机 构: 河北省肿瘤研究所,河北省磁县肿瘤研究所
• 出 处: 肿瘤防治研究
• 发表日期: 1999年03期
• 关键词: 血清总唾液酸 化学比色法 食管上皮 人群筛查 有显著性差异 上皮细胞增生 无显著性差异 肺癌患者血清 高发人群 方差分析

目的：探讨血清总唾液酸对食管癌早诊的作用。方法：采用化学比色法对我国食管癌高发区之一—磁县１５１０例普查人群的血清总唾液酸（ＴＳＡ）分析研究。结果：高发人群血清ＴＳＡ含量随食管上皮细胞增生加重逐渐增加。方差分析显示食管癌、近癌、重增Ⅱ与重增Ⅰ、轻增、正常人群血清ＴＳＡ含量具有显著性差异（Ｐ＜００１），食管各级病变血清ＴＳＡ含量两两比较的ｑ检验结果表明：在食管上皮细胞重增Ⅱ时ＴＳＡ含量与正常人群就有显著性差异（Ｐ＜００１），而重增Ⅰ、轻增和正常人群ＴＳＡ无显著性差异（Ｐ＞００５）。结论：提示血清ＴＳＡ含量可作为一种食管癌早诊指标用于人群筛查工作

Objective: To investigate the role of serum total sialic acid in the diagnosis of esophageal cancer. Methods: The serum total sialic acid (TSA) of 1510 population in Ci County, one of the high-incidence areas of esophageal cancer in China, was analyzed by chemical colorimetry. RESULTS: Serum TSA levels in high-risk populations increased gradually with aggravation of esophageal epithelial cell proliferation. Analysis of variance showed that there were significant differences in serum TSA levels between esophageal cancer, near cancer, hyperintensity II and re-growth I, light increase, and normal population (P<001), q test of TSA content in esophageal lesions at each level. The results showed that there was a significant difference in TSA levels between the esophageal epithelial cells after re-growth II (P<001), but there was no significant difference between the re-increase I and light increase and the normal population (P>005). ). Conclusion: It is suggested that serum TSA level may be used as a marker for early diagnosis of esophageal cancer for population screening