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为评价血清学及（１４）￣Ｃ－尿素呼气试验在治疗幽门螺杆菌（Ｈｐ）感染疗效监测价值，本研究中第一阶段对４２例Ｈｐ感染，患者在抗Ｈｐ治疗前、停药１、３、６、１２个月同期进行胃镜检查、（１４）￣Ｃ－尿素呼气试验及血清ＨｐＩｇＧ抗体测定。分析患者停药１年内随访期呼气试验及血清学变化规律，制定出以呼气试验高于界限值、血清学吸光度（Ａ）值比治疗前下降＜１５％为判断Ｈｐ阳转的疗效监测标准。第二阶段在另一批共６３例疗效监测患者中验证该标准，结果在停药６、１２个月呼气试验敏感性均为１００．０％，特异性分别为９５．５％及１００．０％；血清学敏感性均为１００．０％，特异性分别为５０．０％及８３．３％。结合两种方法的优缺点，提出在不同时期采用（１４）￣Ｃ－尿素呼气试验或血清学检测对治疗Ｈｐ感染进行疗效监测的联合方案。
In order to evaluate the serological and (14) C-urea breath test in the treatment of Helicobacter pylori (Hp) infection, 42 patients with Hp infection were treated in the first phase of the study. Before the anti-Hp treatment, patients discontinued 1 , 3,6,12 months at the same period endoscopy, (14) ~ C-urea breath test and serum HpIgG antibody. Analysis of patients with withdrawal within 1 year follow-up breath test and serological changes, developed to breath test above the threshold value, serum absorbance (A) value decreased than before treatment <15% To determine the efficacy of Hp yang rotation monitoring standard. In the second phase, the standard was verified in another 63 patients with curative effect monitoring. The results showed that the sensitivity of breath test was 100.0% and the specificity was 95.5% and 100, respectively. 0%. The serological sensitivities were 100.0% and the specificity were 50.0% and 83.3% respectively. Combining the advantages and disadvantages of the two methods, a combination regimen of monitoring the curative effect of Hp infection in different periods using (14) C-urea breath test or serological test is proposed.