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目的探讨急性冠状动脉(冠脉)综合征(ACS)患者可溶性细胞粘附因子(s CAM)变化及其临床意义。方法 61例急性冠脉综合征患者,通过冠脉造影、心电、心肌酶变化分为急性ST段抬高心肌梗死组(STEMI组,20例)、急性非ST段抬高心肌梗死组(NSTEMI组,19例)、不稳定型心绞痛组(UAP组,22例),同时选取同期住院稳定型心绞痛患者20例(SAP组)及非冠心病健康者20例(对照组)。采用酶联免疫吸附试验(ELISA)方法测定所选试验对象血清s CAM浓度变化。结果 ACS各亚组可溶性细胞间粘附因子-1(s ICAM-1)、可溶性血管细胞粘附因子-1(s VCAM-1)浓度明显高于SAP组及对照组,差异有统计学意义(P<0.05)。SAP组s ICAM-1、s VCAM-1浓度高于对照组,但差异无统计学意义(P>0.05)。结论 ACS发生发展与s CAM有密切关系。
Objective To investigate the changes of soluble cell adhesion molecule (s CAM) in patients with acute coronary syndrome (ACS) and its clinical significance. Methods Sixty-one patients with acute coronary syndrome were divided into acute ST-elevation myocardial infarction group (STEMI group, 20 cases), acute non-ST-elevation myocardial infarction group (NSTEMI group) by coronary angiography, , 19 cases), unstable angina pectoris group (UAP group, 22 cases). At the same time, 20 patients with stable angina pectoris (SAP group) and 20 healthy people without coronary heart disease (control group) were enrolled in this study. The changes of serum CAM concentrations in the selected subjects were measured by enzyme-linked immunosorbent assay (ELISA). Results The concentrations of soluble intercellular adhesion molecule-1 (s ICAM-1) and soluble vascular cell adhesion molecule-1 (s VCAM-1) in ACS subgroups were significantly higher than those in SAP and control groups P <0.05). The concentration of ICAM-1, s VCAM-1 in SAP group was higher than that in control group, but the difference was not statistically significant (P> 0.05). Conclusion The occurrence and development of ACS is closely related to s CAM.