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目的 探讨血清生长分化因子15(GDF-15)、肌钙蛋白I(cTnI)水平与心肺复苏患者近期预后的关系.方法 入选104例于河南省人民医院急诊科发生心脏骤停并实施心肺复苏(CRP)成功的患者,在患者CPR成功后分别在立即(0 h)、12 h、24 h采用酶联免疫吸附试验(ELISA)检测GDF-15,采用全自动生化分析仪检测cTnI.根据GDF-15变化情况将患者分为A组(34例,GDF-15无明显改变)、B组(32例,GDF-15逐渐升高)和C组(38例,GDF-15先升高后下降).结果 三组患者GDF-15和cTnI水平在CPR后均显著升高(P均＜0.05),12 h时B组和C组患者GDF-15和cTnI水平均显著高于A组(P均＜0.05),24 h时A组、B组、C组三组GDF-15和cTnI水平有差异(P均＜0.05).B组患者死亡率、心力衰竭和非致死性心肌梗死发生率高于其余两组,GDF-15与cTnI呈正相关(r=0.938,P=0.009).结论 心脏骤停患者CPR后血清GDF-15、cTnI均有上升,且二者呈正相关,二者联合可用于预测患者CPR预后.“,”Objective To discuss the relationship among levels of serum growth differentiation factor-15 (GDF-15), cardiac troponin I (cTnI) and short-term prognosis in patients with cardiopulmonary resuscitation (CPR). Methods The patients (n=104) with sudden cardiac arrest undergone success CRP were chosen from Emergency Department of People’s Hospital of Henan Province. The level of GDF-15 was detected by using ELISA and level of cTnI was detected by using automatic biochemical analyser immediately (0 h) and after CPR for 12 h and 24 h. The patients were divided, according to GDF-15 changes, into group A (n=34, without GDF-15 changes), group B (n=32, with gradually increased GDF-15) and group C (n=38, with increased and then decreased GDF-15). Results The levels of GDF-15 and cTnI increased significantly after CPR in all 3 groups (all P<0.05). The levels of GDF-15 and cTnI were significantly higher in group B and group C than those in group A after CPR for 12 h (all P<0.05), and had difference among 3 groups after CPR for 24 h (all P<0.05). The mortality and incidence of heart failure and non-lethal myocardial infarction were higher in group B than those in other 2 groups, and GDF-15 was positively correlated to cTnI (r=0.938, P=0.009). Conclusion The levels of GDF-15 and cTnI will increase in patients with sudden cardiac arrest after CPR, and GDF-15 and cTnI are positively correlated to each other. The levels of GDF-15 and cTnI can be taken to predict prognosis in patients after CPR.