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AIM:To investigate the difference of amino acid uptakebetween normal and cancerous colon tissues.METHODS:Sixteen patients with colon cancer wereenrolled in our study.Blood samples were taken duringoperations,serum amino acid concentrations of blood fromcancerous or normal colon were analyzed.Amino aciduptake rate was calculated by the A-V difference andevaluated statistically.RESULTS:Except for methionine,the uptake rate of aminoacids in cancer was higher than that in normal colon(25.01% vs-2.29%,P<0.01).The amino acid uptake ratedid not correlate to the size of tumor mass (P>0.05).Therewas no statistical significance in the amino acid uptakerate according to the Dukes stage,though it was higher inpatients with Dukes stage C or D than that with Dukesstage B (P>0.05).CONCLUSION:Abnormal synthetic metabolism of coloncancer may contribute to its higher amino acid uptake ratethan that of normal colon.
To investigate the difference of amino acid uptake between normal and cancerous colon tissues. METHODS: Sixteen patients with colon cancer wereenrolled in our study. Blood samples were taken during surgery, serum amino acid concentrations of blood from cancerous or normal colon were analyzed. Amino acid uptake rate was calculated by the AV difference an evaluated value. [00132] The results are as follows: Except for methionine, the uptake rate of aminoacids in cancer was higher than that in normal colon (25.01% vs-2.29%, P <0.01) the size of tumor mass (P> 0.05). There was no statistical significance in the amino acid uptake rate according to the Dukes stage, though it was higher in patients with Dukes stage C or D than that with Dukes stage B (P> 0.05). CONCLUSION: Abnormal synthetic metabolism of coloncancer may contribute to its higher amino acid uptake ratethan that of normal colon.