,Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures

• 作 者: Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao
• 机 构: Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong U
• 出 处: 药学学报（英文版）
• 发表日期: 2018年3期
• 关键词: Raman imaging Surface-enhanced Raman scattering Nanoprobes Architecture Biomedic

Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surface-enhanced Raman scattering (SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications. In this review we elaborate on recent progress in design strategies with emphasis on material properties, modifying factors, and structural parameters.