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目的：探索黄苓中的放射损伤防护作用有效成分。方法：黄芩水提液酸化保温（８０℃）５０ 分钟，滤去析出的黄芩黄酮类（ Ｆ Ｓ Ｂ Ｇ） ，水溶液用经典分离法得一沉淀物（ Ⅰ） 、化学分析其结构类型；用６０ Ｃｏ ７ ．７ Ｇｙ ～８ ．７ Ｇｙ 全身照射纯系 Ｎ Ｉ Ｈ 雌性小鼠，照前３５ ～４５ ｍｉｎ 每鼠腹腔注射（ Ⅰ）１ｇ／ｋｇ 或２ｇ／ｋｇ ，观察生存防护效力、３０ 天存活率和照射４．０ Ｇｙ（２ｇ／ｋｇ） 后第４ 天和第１２ 天的 Ｗ Ｂ Ｃ、 Ｐ Ｌ Ｔ、 Ｒ Ｂ Ｃ 和 Ｈ Ｇ Ｂ。结果：（１） Ｆ Ｓ Ｂ Ｇ 和（ Ⅰ） 均对三氯化铁、 Ｍｏｌｉｓｃｈ 、 Ｆｅｈｌｉｎｇ 试剂呈阳性反应，前者对浓硫酸、碱试液和盐酸镁粉呈阳性而（ Ⅰ） 呈阴性；（２） 每鼠１ ｇ／ｋｇ 和２ ｇ／ｋｇ 剂量均显著提高生存防护效力（１ ．３５ ～２ ．０８ 治疗组３０ 天存活时间和对照组３０ 天存活时间之比值） 和３０ 天存率（ 治疗组为８．３３～４１ ．４６ ％ ， 对照组为０ ～２ ．５０ ％ ） ，２ ｇ／ ｋｇ 能明显增加４．０ Ｇｙ 照后第４ 天和第１２ 天的 Ｗ Ｂ Ｃ、 Ｐ Ｌ Ｔ、 Ｒ Ｂ Ｃ 和 Ｈ Ｇ Ｂ。结论：（１） 对浓硫酸等的呈色反应差异表明（ Ⅰ） 和 Ｆ Ｓ Ｂ Ｇ 化学结构不同；对 Ｆｅ
Objective: To explore the effective components of radiation damage protection in Astragalus membranaceus. Methods: Astragalus membranaceus aqueous extracts were incubated at 80°C for 50 minutes, and the precipitated flavone glycosides (FS BG) were filtered off. The aqueous solution was precipitated with a classical separation method (I) and its structure type was chemically analyzed; Co 7 . 7 Gy ~8. 7 Gy of whole body irradiated pure NIH female mice was injected intraperitoneally (I) 1g/kg or 2g/kg every 35 to 45 min before irradiation to observe the efficacy of survival protection, 30-day survival rate and irradiation 4.0 Gy ( W B C, P L T, R B C, and H G B on day 4 and day 12 after 2 g/kg). RESULTS: (1) Both F S B G and (I) were positive for ferric chloride, Molisch, and Fehling reagents. The former was positive for concentrated sulfuric acid, alkaline test solution, magnesium chloride powder, and (I) was negative; 2) The doses of 1 g/kg and 2 g/kg per mouse significantly improved the efficacy of survival protection (the ratio of the 30-day survival time of the treatment group to the 30-day survival time of the control group) and the 30-day survival rate ( The treatment group was from 8.33 to 41.46%, and the control group was from 0 to 2.5%, and the 2 g/kg was significantly increased by 4.0 Gy. WBC and PL on the 4th and 12th days after irradiation. T, R B C, and H G B. Conclusions: (1) Differences in the color reaction of concentrated sulfuric acid, etc. indicate that the chemical structures of (I) and F S B G are different; for Fe