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目的:观察丹红注射液治疗周围动脉闭塞症的临床疗效及不良反应。方法:选择周围动脉闭塞症80例,随机分为观察组和对照组各40例。两组均采用包括戒烟,防止寒冷、潮湿,患肢适当保暖、锻炼,并根据病情选用抗凝血及镇痛药等的常规治疗。在此基础上,观察组采用丹红注射液40ml加入5%的葡萄糖或生理盐水500ml静脉滴注治疗;对照组采用红花注射液40ml加入5%的葡萄糖或生理盐水500ml静脉滴注治疗。两组均每天1次,15天为1个疗程。观察两组临床疗效及不良反应。结果:观察组总有效36例,有效率90.0%;对照组23例,有效率57.5%。两组比较,差异非常显著(P<0.01)。两组均未发生严重不良反应。结论:常规加丹红注射液治疗周围动脉闭塞症疗效较好,且较安全。
Objective: To observe the clinical effects and adverse reactions of Danhong injection in the treatment of peripheral arterial occlusive disease. Methods: Eighty patients with peripheral arterial occlusive disease were randomly divided into observation group (40 cases) and control group (40 cases). Both groups are used, including smoking cessation, to prevent cold, damp, appropriate limb warmth, exercise, and according to the condition of the selection of anticoagulant and analgesics and other conventional treatment. On this basis, the observation group using Danhong injection 40ml added 5% glucose or saline 500ml intravenous infusion; control group with safflower injection 40ml added 5% glucose or saline 500ml intravenous infusion. Both groups were given once daily for 15 days as a course of treatment. The clinical efficacy and adverse reactions of the two groups were observed. Results: The observation group, the total effective 36 cases, the effective rate was 90.0%; control group, 23 cases, the effective rate was 57.5%. The differences between the two groups were significant (P <0.01). No serious adverse reactions occurred in both groups. Conclusion: Conventional Jia Danhong injection in the treatment of peripheral arterial occlusive disease is better and safer.