A Novel Guided Bone Regeneration Membrane Composed of Nano-hydroxyapatite and Aliphatic Polyester-am

• 作 者: 邓霞 陈治清
• 机 构: West China College of Stomatology Sichuan University Chengdu 610041 China,West China College of Sto
• 出 处: Journal of Wuhan University of Technology-Materials Science
• 发表日期: 2005年S1期
• 关键词: hydroxyapatite Regeneration Membrane amide elsewhere copolymer hasbeen Instron a

Hydrothermally synthesized nano-hydroxyapatite (n-HA) varing in weight from 10% to 30% was used as filler to make guided bone regeneration (GBR) composite membranes with novel aliphatic polyesteramide (PEA). The structure and properties of PEA and its n-HA composites were investigated through TEM, IR, XRD, SEM and EDX. The shape and size of the n-HA crystals are similar to the apatite crystals in natural bone. Molecule interactions are present between the n-HA and PEA in the composite, which allows the uniform dispersion of n-HA in PEA matrix. This contributes enhanced mechanical property and bioactivity to the composite. The cytocompatibility of the composites has been investigated by culturing osteoblasts on the membranes. Good cell attachment and proliferation manner were observed on the membranes after 1 week. These results suggest that the PEA/n-HA composite membrane prepared in this study may serve as barrier membranes for guided bone regeneration and potential candidate scaffold for tissue engineering.

Hydrothermally synthesized nano-hydroxyapatite (n-HA) varing in weight from 10% to 30% was used as filler to make guided bone regeneration (GBR) composite membranes with novel aliphatic polyesteramide (PEA). The structure and properties of PEA and its n -HA composites were investigated through TEM, IR, XRD, SEM and EDX. The shape and size of the n-HA crystals are similar to the apatite crystals in natural bone. Molecule interactions are present between the n-HA and PEA in the composite This allows the uniform dispersion of n-HA in PEA matrix. This contributes enhanced mechanical property and bioactivity to the composite. The cytocompatibility of the composites has been investigated by culturing osteoblasts on the membranes. Good cell attachment and proliferation manner were observed on the membranes after 1 week. These results suggest that the PEA / n-HA composite membrane prepared in this study may serve as barrier membranes for guided bone regeneration and potential candidate scaffold for tissue engineering.