阿伦磷酸钠通过抑制脊髓小胶质细胞的激活治疗神经病理性疼痛

• 作 者: Yao Y 张建
• 出 处: 中国疼痛医学杂志
• 发表日期: 2016年06期
• 关键词: 阿伦磷酸钠 小胶质细胞 神经病理性疼痛 神经病理痛 中枢敏化 脊髓 骨质疏松 慢性压迫 大鼠 二磷酸盐

阿伦磷酸钠(ALN)是一种含氮二磷酸盐,常用于治疗骨质疏松。有文献报道,ALN可缓解疼痛,但其机制不清。神经病理痛的发病机制包括外周敏化和中枢敏化。脊髓小胶质细胞MAPK通路的激活引起中枢敏化,进而介导慢性疼痛的发生。研究目的:ALN是否通过抑制小胶质细胞激活,缓解神经病理痛。方法:(1)建立坐骨神经慢性压迫性损伤(CCI)模型。(2)大鼠鞘内或腹腔内注射ALN。(3)用von Frey纤维

Allergic sodium phosphate (ALN) is a nitrogen-containing diphosphate commonly used in the treatment of osteoporosis. It has been reported in the literature that ALN can relieve pain, but its mechanism is unclear. The pathogenesis of neuropathic pain includes peripheral sensitization and central sensitization. Activation of the MAPK pathway in the spinal microglia induces central sensitization, which in turn mediates the onset of chronic pain. Research purposes: ALN whether through the inhibition of microglia activation, relieve neuropathic pain. Methods: (1) To establish chronic constriction injury (CCI) model of sciatic nerve. (2) Rats were injected with intrathecal or intraperitoneal ALN. (3) with von Frey fiber