Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoa

• 作 者: Zhen-Bang Lou Xin-Long Pang Chao Chen Li-Rong Wen Ming Li
• 机 构: College of Chemistry and Molecular Engineering Qingdao University of Science and Technology,Key Labo
• 出 处: Chinese Chemical Letters
• 发表日期: 2015年10期
• 关键词: catalyzed aromatic cyclization initiated cascade equiv carbonyl esters bromo rea

The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.

The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.