高度近视蛋白质组学研究及展望

• 作 者: 薛敏
• 机 构: 天津医科大学眼科医院 天津医科大学眼视光学院 天津医科大学眼科研究所 天津市视网膜功能与疾病重点实验室 天津市眼科学与视觉科学国际联合研究中心 300384;薛敏现在安徽省第二人民医院眼科，合肥 23
• 出 处: 中华实验眼科杂志
• 发表日期: 2021年12期
• 关键词: Myopia/etiology Proteomics Review High myopia

高度近视是全世界低视力和致盲眼病的主要原因之一，并且有着日渐严峻的形势，已造成严重的经济和社会负担，然而其发病机制复杂，目前尚未完全阐明。近年来，随着生物学技术的不断进步，利用蛋白质组学技术寻找高度近视动物模型和患者组织中差异表达的功能蛋白质，以期获得与高度近视相关的特异性生物学标志物，为探索高度近视发病机制、诊断方法和治疗措施提供新的思路。本文就高度近视的临床特点、蛋白质组学研究内容及策略、高度近视蛋白质组学在模型动物眼组织和患者血液、晶状体、房水中的研究进展进行综述，分析蛋白质组学技术在高度近视研究中的突出优势和已有成果，从功能蛋白视角探索高度近视的病理机制，为开发具有治疗价值的特异性分子药物提供理论依据。“,”As one of the main causes of low vision and blindness in the world, high myopia has become increasingly serious and caused heavy economic and social burden.However, its pathogenesis is complex and has not been fully clarified yet.In recent years, with the continuous progress of biological technology, proteomic technology has been used to find differentially expressed functional proteins in animal models and tissues of high myopic patients in order to obtain specific biological markers related to high myopia, and to provide new insights for exploring the pathogenesis, diagnosis methods and treatment of high myopia.In this article, the clinical characteristics of high myopia, the research content and strategies of proteomics, the research progress of proteomics in high myopia studying eye tissues of model animals and the blood, lens and aqueous humor of patients were reviewed, the outstanding advantages and achievements of proteomic technology in the study of high myopia were analyzed, and the pathological mechanism of high myopia was explored from the perspective of functional proteins, which would provide a theoretical basis for the development of specific molecular drugs with therapeutic value.