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为研究宫颈癌及癌前期病人姐妹染色单体交换(SCE)频率的变化,作者对46名宫颈癌病人,89名宫颈癌前期病人及43名正常对照妇女进行了外周血淋巴细胞SCE分析.结果表明,SCE频率在癌期病人,癌前期病人及对照组分别为10.15±2.49,8.83±2.15和7.55±2.24.癌期及癌前期病人的SCE频率较对照组明显升高(p<0.001).89名癌前期病人据病理严重程度不同分为轻、中、重度三组,轻度组39名,中度组38名,重度组12名.SCE频率在轻、中、重三组
In order to study the changes of sister chromatid exchange (SCE) frequency in cervical cancer and precancerous patients, the author conducted SCE analysis of peripheral blood lymphocytes in 46 cervical cancer patients, 89 cervical precancerous patients and 43 normal control women.Results The results showed that the frequency of SCE was 10.15 ± 2.49, 8.83 ± 2.15 and 7.55 ± 2.24 in cancer patients, precancerous patients and controls, respectively. The frequency of SCE in cancer patients and precancerous patients was significantly higher than that in control group (p <0.001). 89 pre-cancerous patients were divided into mild, moderate and severe groups according to their pathological severity, 39 mild patients, 38 moderate patients and 12 severe patients. The frequency of SCE in light, moderate and severe groups