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目的分析肾移植供受体人类白细胞抗原错配与术后并发恶性肿瘤的关系。方法回顾性分析27例患者临床资料,重点分析供受体人类白细胞抗原A、B、和DR3个位点共6个抗原的错配情况。结果人类白细胞抗原半相合以上的患者156例,其中20例(12.82%)发生恶性肿瘤,人类白细胞抗原半相合以下的患者215例,其中7例(3.26%)发生恶性肿瘤,两组差异显著(P<0.05),人类白细胞抗原半相合以上的男性和女性患者分别为2例(10.0%)、18例(90.0%),说明人类白细胞抗原半相合以上的男女比例存在显著差异(P<0.05)。结论肾移植供受体人类白细胞抗原错配数与术后并发恶性肿瘤之间有着紧密联系。
Objective To analyze the relationship between mismatch of human leukocyte antigen and recipient of malignant neoplasm after renal transplantation. Methods The clinical data of 27 patients were retrospectively analyzed. The mismatch situation of 6 antigens on A, B, and DR3 sites of human leukocyte antigen was analyzed. Results Of 156 patients with haploidentical leukocyte antigen haplotype, 20 (12.82%) had malignant tumors and 215 under the haploidentical human leukocyte antigen haplotype, of which 7 (3.26%) had malignant tumors with significant difference between the two groups 2 cases (10.0%) and 18 cases (90.0%) respectively, indicating that there was a significant difference (P <0.05) in the proportion of men and women on haploidentical leukocyte antigen haplotype . Conclusion There is a close relationship between the mismatch number of donor leukocyte antigen and the postoperative malignant tumor in renal transplantation.