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研究目标是建立通用的纳米级表面涂层技术, 修改粗糙的钛表面化学牙种植体,同时保持微米级水平的表面形貌。以表面形貌调控表面化学,可能会引起生物活性、加速植入种植体表面的整合、缩短移植后的愈合时间。羟基磷灰石(HA)具有生物相容性和骨传导材料特点,HA 涂层具有促进骨骼生长的优点,但涂层易脱落,有混合晶相弊端。本文介绍了凯美特(Chemat)公司的一项新技术(BioFun),即设计一种新型室温自组装,在粗糙度为微米级水平的植体表面来制备纳米级促进骨生长表面。表面经过发射扫描电镜,X 射线光电子能谱,EDS 和 SMM 分析得到表征。生物相容性和生物植入物的表面活性研究在动物体外和体内进行。在动物体外,大鼠骨髓基质干细胞培养试验表明新型植体表面技术是生物相容的,也是无毒的。纳米羟基磷灰石植入已通过官能 10993 生物相容性面板测试。实验植入物或无 HA 纳米粒子的手术放置在植入大鼠股骨和推入式测试后 2 个星期愈合。这些数据表明,HA 纳米粒子沉积加速早期骨整合的过程,可能增加其剪切粘结强度。总之,BioFun 技术可创建一个纳米尺度的成骨表面,HA 纳米颗粒沉积并没有改变钛基板的预期微观形貌,而创造了新的纳米级形貌,这明显有利于加速骨植入的融合。
The goal of the study was to establish a common nanoscale surface coating technique that would modify rough titanium surface chemical dental implants while maintaining micron-level surface topography. Controlling the surface chemistry with surface topography may result in bioactivity that accelerates the integration of the implanted implant surface and shortens the healing time after implantation. Hydroxyapatite (HA) has the characteristics of biocompatibility and bone conduction material. The HA coating has the advantage of promoting bone growth, but the coating is easy to fall off and has the disadvantages of mixed crystal phase. This article describes a new technology from Biomat Inc., a new type of self-assembly at room temperature, for the preparation of nanoscale osteoinductive growth surfaces at the surface of micrometer-scale implants. The surface was characterized by emission scanning electron microscopy, X-ray photoelectron spectroscopy, EDS and SMM analysis. Biocompatibility and surfactant studies of biological implants are performed in animals and in vivo. In vitro, rat bone marrow stromal stem cell culture assays show that the novel implant surface technology is biocompatible and non-toxic. Nano-hydroxyapatite implants have been tested by functional 10993 biocompatible panels. Surgical placement of either experimental implants or HA-free nanoparticles healed 2 weeks after implantation in the rat femur and push-in test. These data suggest that HA nanoparticle deposition accelerates the process of early osseointegration, possibly increasing its shear bond strength. In summary, BioFun technology creates a nanoscale osteogenic surface. The HA nanoparticle deposition does not alter the expected microstructure of the titanium substrate, creating a new nanoscale morphology that is clearly beneficial for accelerating the fusion of bone implants.