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联合用药时,由于体内药物之间或药物—机体—药物之间的反应,可改变药物原来的体内过程及组织对药物的敏感性,产生单独药物所没有的有益或有害的作用。本文概述地高辛与抗心律失常药联合应用的临床药理。一、地高辛与奎尼丁奎尼丁是应用历史较久的抗心律失常药,尽管目前有很多抗心律失常药介绍到临床,但在慢性心律失常的治疗中,该药仍然是一种重要的药物。治疗慢性房颤、房扑时,常先用强心甙减慢心室率,再用奎尼丁转复为窦性心律。近期研究表明,服用奎尼丁24h血浆地高辛浓度就开始升高,大约经过4d达到新的血浆稳态浓度。其浓度改变程度与奎尼丁的剂量成正比,但有明显个体差异,有的升高4倍,平均升高2
Combination therapy, due to the drug in the body or between the drug - body - drugs can change the original drug in vivo process and tissue sensitivity to drugs, resulting in a single drug does not have beneficial or harmful effects. This article summarizes the clinical pharmacology of digoxin and antiarrhythmic agents in combination. First, digoxin and quinidine quinidine is a long history of anti-arrhythmic drugs, although there are many anti-arrhythmic drugs introduced to the clinic, but in the treatment of chronic arrhythmia, the drug is still a Important drug. Treatment of chronic atrial fibrillation, atrial flutter, often first with cardiac glycosides slow ventricular rate, and then converted to quinidine sinus rhythm. Recent studies have shown that plasma quinidine concentrations started to rise 24 hours after taking quinidine, reaching a new steady-state plasma concentration after about 4 days. The concentration of quinidine and the degree of change is proportional to the dose, but significant individual differences, and some 4 times increased, with an average increase of 2