穿心莲通过阻滞电压调控的钙通道和抑制钙离子内流引起子宫松弛

• 作 者: 张莉
• 出 处: 国外医药(植物药分册)
• 发表日期: 2002年03期
• 关键词: 钙离子内流 钙通道 醇提取物 收缩反应 粗提取物 子宫平滑肌 再灌注损伤 大鼠 子宫松弛 心肌缺血再灌注

穿心莲的粗提取物可预防狗因再灌注损伤引起的心肌缺血,该作用与其在心肌缺血再灌注过程中降低 Ca~(2+)超载有关。因而推测该植物可影响钙介导的收缩反应并引起平滑肌松弛。在该项研究中作者证实了穿心莲可阻滞电压调控的钙通道并抑制经雌二醇处理的大鼠子宫平滑肌 Ca~(2+)内流。实验用该植物的70%乙醇提取物(含6%穿心莲内酯)。SD 雌性大鼠肌肉注射1

Crude extract of Andrographis paniculata can prevent myocardial ischemia caused by reperfusion injury in dogs, and this effect is related to reducing Ca 2+ overload during myocardial ischemia-reperfusion. Therefore, it is speculated that the plant can affect the calcium-mediated contraction response and cause smooth muscle relaxation. In this study, the authors confirmed that andrographolide can block voltage-regulated calcium channels and inhibit Ca2+ influx in uterine smooth muscle of rats treated with estradiol. The experiment used 70% ethanol extract of the plant (containing 6% andrographolide). SD female rats intramuscularly 1