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本文观察２０例正常人和２０例慢性肾功能衰竭（ＣＲＦ）患者血糖、血清胰岛素（ＩＮＳ）、Ｃ－肽（Ｃ－Ｐ）和生长激素（ＧＨ）释放水平。结果表明：ＣＲＦ患者在口服葡萄糖耐量试验中出现糖耐量低减（ＩＧＴ）者占４０％，同时伴ＩＮＳ升高，其余患者耐糖曲线、ＩＮＳ释放曲线基本正常。ＣＲＦ患者血清Ｃ－Ｐ显著高于正常，但ＩＧＴ组与耐糖正常（ＮＧＴ）组Ｃ－Ｐ无显著差异。ＣＲＦ患者血ＧＨ显著高于正常对照组，ＩＧＴ组与ＮＧＴ组血清ＧＨ空腹水平无明显差异。但餐后各时相均显著高于ＮＧＴ组，不被葡萄糖抑制，提示ＣＲＦ时血清ＣＨ升高，可能是导致部分ＣＲＦ患者出现ＩＧＴ的原因之一。
In this paper, the levels of blood glucose, serum insulin (INS), C-peptide (P-P) and growth hormone (GH) were measured in 20 normal subjects and 20 patients with chronic renal failure (CRF) The results showed that patients with CRF had an incidence of impaired glucose tolerance (IGT) in oral glucose tolerance test, accounting for 40%, accompanied by an increase in INS. The remaining patients had normal glucose tolerance curve and INS release curve. Serum C-P levels in patients with CRF were significantly higher than those in normal controls, but there was no significant difference in C-P levels between IGT and NGT groups. Blood GH in patients with CRF was significantly higher than that of the normal control group, serum GH levels in IGT group and NGT group had no significant difference. However, the postprandial levels were significantly higher than the NGT group, not inhibited by glucose, suggesting that elevated serum CH in patients with CRF may be one of the reasons leading to the emergence of IGT in some CRF patients.