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目的通过对采用替勃龙替代治疗的绝经后妇女的血脂变化的观察,探讨替勃龙对绝经后妇女血脂代谢的影响。方法 68例绝经后妇女,分为替勃龙组和对照组,替勃龙组每日口服替勃龙1片,持续1年,对照组不服用任何药物。替勃龙组观察治疗前后的改良Kupperman评分变化、治疗前及治疗后1年的血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及空腹血糖(FBG)水平。对照组观察1年前后的上述指标。结果替勃龙组改良Kupperman评分治疗1年后出现显著降低(P<0.01)。替勃龙组各项血脂水平均出现下降,其中治疗后TG为(0.82±0.44)mmol·L-1,与治疗前(1.30±0.95)mmol·L-1相比显著降低(P<0.01);治疗后HDL为(1.35±0.33)mmol·L-1,与治疗前(1.54±0.29)mmol·L-1相比显著降低(P<0.01)。与对照组比较,TG和HDL有显著差异(P<0.05)。结论替勃龙可显著改善绝经后女性相关症状并且对绝经后妇女的脂肪代谢紊乱有一定的改善效果。
Objective To investigate the effects of tibolone on blood lipid metabolism in postmenopausal women through observing the changes of blood lipids in postmenopausal women treated with tibolone replacement therapy. Methods A total of 68 postmenopausal women were divided into two groups: tibolone group and control group. One tibolone group was given tibolone daily for 1 year while the control group did not take any drug. The changes of modified Kupperman score before and after treatment were observed in tibolone group. The levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) And fasting blood glucose (FBG) levels. Control group observed 1 year before and after the above indicators. Results The tibolone group improved significantly Kupperman score after 1 year (P <0.01). The blood lipid levels of tibolone group decreased, and the TG value after treatment was (0.82 ± 0.44) mmol·L-1, which was significantly lower than that before treatment (1.30 ± 0.95) mmol·L-1 (P0.01) (1.35 ± 0.33) mmol·L-1 after treatment, which was significantly lower than that before treatment (1.54 ± 0.29 mmol·L-1) (P <0.01). Compared with the control group, there was a significant difference between TG and HDL (P <0.05). Conclusion Tibolone can significantly improve the postmenopausal women related symptoms and the improvement of fat metabolism disorders in postmenopausal women.