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1971年,Nair等首先在牛的下丘脑中分离到L-脯氨酸-L-亮氨酸-甘氨酰胺(PLG),由于它具有抑制黑色素细胞刺激激素(MSH)释放的作用,故又称为黑色素细胞刺激激素释放抑制因子(MIF)。此后,很多作者在动物实验和临床应用方面进行了广泛、深入的研究,包括药理学、作用机制和生理功能等。结果证明PLG具有多种中枢神经系统作用。值得注意的是它具有抗帕金森病(PD)的作用。本文将近年来国内外对PLG在上述方面的研究成就综述如下。一、药理学在大白鼠中注入同位素~(14)C标记的PLG后,发现PLG在血浆中的半衰期为9分钟,
In 1971, Nair et al. First isolated L-proline-L-leucine-glycinamide (PLG) from the hypothalamus of cattle. Because of its inhibitory effect on the release of melanocyte-stimulating hormone (MSH) Known as melanocyte-stimulating hormone releasing factor (MIF). Since then, many authors have conducted extensive and in-depth research in animal experiments and clinical applications, including pharmacology, mechanism of action and physiological functions. The results show that PLG has a variety of central nervous system effects. It is noteworthy that it has anti-Parkinson’s disease (PD) role. In this paper, we summarize the research achievements of PLG in the above aspects at home and abroad in recent years. First, pharmacology In rats injected with isotope ~ (14) C-labeled PLG and found that PLG in plasma half-life of 9 minutes,