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报告国产全反式维甲酸诱导分化治疗13例急性早幼粒细胞白血病。均为初治患者,皆经未捎血象,骨髓象及组化确诊;男4例,女9例;年龄10～51岁,平均26岁。服药60～80mg/d,疗程36～55d,平均43d,总药量2 480～3 480mg,平均3000mg。13例中12例获完全缓解,1例死于DIC,完全缓解率达92％(12/13)。强调对并发症的治疗和缓解后继续巩固化疗。表明单用本药治疗优于一般联合化疗。
Report the domestic induced all-trans retinoic acid induced differentiation of 13 cases of acute promyelocytic leukemia. All of them were newly diagnosed patients. All of them were diagnosed as having not taken blood, bone marrow and histological diagnosis. There were 4 males and 9 females, aged from 10 to 51 years with an average of 26 years old. Medication 60 ~ 80mg / d, course of treatment 36 ~ 55d, an average of 43d, the total dose of 2 480 ~ 3 480mg, an average of 3000mg. Of the 13 patients, 12 had complete remission and 1 died of DIC, with a complete response rate of 92% (12/13). Emphasis on the treatment of complications and mitigation continue to consolidate chemotherapy. Show that single drug treatment is superior to the general combination chemotherapy.