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由于哮喘的发病原理尚未阐明,平喘药的含意就难于明确。从广义来说,凡能平定喘息症状的药物均称为平喘药。但以往,平喘药实质上是指支气管扩张药,近年来发现了过敏介质阻释药色甘酸钠,扩大了平喘药的范围。因此,筛选平喘药至少应从支气管平滑肌松弛作用和抗过敏作用两方面着手。本文仅就这两个方面讨论筛选平喘药的方法。气管及支气管平滑肌松弛作用的筛选法一、离体气管法1.动物选择:不同动物的气管对药物反应的差异是预测药物对人作用的一个重要因素。从常用的实验
As the pathogenesis of asthma has not yet been clarified, the meaning of antiasthmatic drugs is difficult to clarify. In a broad sense, those who can calm their wheezing symptoms are called antiasthmatics. However, in the past, antiasthmatic drugs essentially refers to bronchodilators, found in recent years, an allergic mediator drug cromolyn, expanding the scope of antiasthmatic drugs. Therefore, the screening of antiasthmatic at least bronchial smooth muscle relaxation and anti-allergic effects should be two aspects. This article only on these two aspects of the method of screening antiasthmatic drugs. Trachea and Bronchial Smooth Muscle Relaxation Screening Method 1. Exotatic Tracheal Method 1. Animal Selection: The differences in tracheal response to different animals are an important factor in predicting the effect of drugs on humans. From commonly used experiments