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目的:总结二期梅毒合并人免疫缺陷病毒(HIV)感染的临床特点和高效抗逆转录病毒治疗(HAART)对驱梅治疗后血清转归的影响。方法 :对42例二期梅毒合并HIV感染者进行病史资料采集、临床体格检查和实验室检查,分析其流行病学特点、临床皮疹特征和治疗后血清滴度的变化。结果:二期梅毒合并HIV感染传播方式均为性接触传播,男男同性传播有27例(27/42,64.3%),为主要感染方式。临床表现以躯干四肢皮肤玫瑰疹为主,共有30例(30/42,71.4%)。接受HAART治疗的11例患者血浆反应素环状卡片试验(RPR)滴度下降快于未接受HAART治疗的31例患者。结论:男男同性恋人群为二期梅毒合并HIV感染高危人群,二期梅毒皮疹形态多种多样,同时接受HAART治疗有利于梅毒RPR滴度的降低。
Objective: To summarize the clinical characteristics of secondary infection with syphilis and human immunodeficiency virus (HIV) infection and the effect of high active antiretroviral therapy (HAART) on serum outcome after the treatment of flooding. Methods: Forty - two cases of secondary syphilis with HIV infection were collected for medical history, physical examination and laboratory tests. The epidemiological characteristics, clinical rash characteristics and serum titers after treatment were analyzed. Results: The transmission of second-stage syphilis combined with HIV infection were all sexually transmitted. There were 27 cases (27 / 42,64.3%) of the same-sex transmission in male patients, which was the main mode of infection. Clinical manifestations of skin and skin rashes mainly torsos, a total of 30 cases (30 / 42,71.4%). Eleven patients treated with HAART had a much lower titers of plasma RPR in 31 patients who did not receive HAART. CONCLUSIONS: Male and gay men are at high risk for second-stage syphilis with HIV infection. The second-stage syphilis rash is diverse in shape. In the meantime, receiving HAART is beneficial for the reduction of syphilis RPR titer.