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人类肺内的内源性一氧化氮（eNO）有调节肺血管的功能，吸人外源性NO可预防肺动脉高压并阻断乙酰胆碱诱导实验动物支气管收缩的作用。已证实吸烟者屏气时其eNO浓度比非吸烟者低，但对吸烟者中低eNO的生理学作用尚无研究，且对非特异性刺激能引起吸烟者气道收缩的正确机制也未阐
Endogenous nitric oxide (eNO) in the human lung regulates pulmonary vascular function. Inhalation of exogenous NO prevents pulmonary hypertension and blocks acetylcholine-induced bronchoconstriction in experimental animals. It has been confirmed that smokers have lower eNO concentrations when they hold their breath than non-smokers, but there is no research on the physiological role of low eNO in smokers, and the correct mechanism of non-specific stimulation that can cause airway contractions in smokers has not been elucidated.