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利用台式飞行时间质谱的中分辨本领,报道了西尼地平的电子轰击质谱的裂解规律,对裂解途径进行了完全的指认.质谱中发现低丰度的分子离子峰的精确质量为m/z492 .190 4(计算值:492 .189 7) .质谱检测到5个较强碎片离子峰( >12 %)可以作为鉴定西尼地平的特征峰.其中3个对应于不含4-硝基苯基的离子:m/z370(100 %) ,254(42 %)和196(17 %) .另外两个m/z117(21 %)和115(12 %)来自酯基的裂解碎片离子.此外,位于m/z375 (2 %)和331(2 %)的低丰度碎片峰也很重要,它们来自含有4-硝基苯基的离子.这一结果对西尼地平的快速鉴定和药理研究提供了重要的实验依据.
Using the mid-resolution technique of bench-top time-of-flight mass spectrometry, the cleavage regularity of cinnabine by electron impact mass spectrometry was reported, and the cleavage route was completely identified. The exact mass of low abundance molecular ion peak found in mass spectrometry was m / z 492. 190 4 (Calculated: 492 .189 7). Mass spectrum 5 strong fragment ion peaks (> 12%) were detected as characteristic peaks for the identification of cilnidipine. Three of them corresponded to the peak without 4-nitrophenyl Of the ions: m / z 370 (100%), 254 (42%) and 196 (17%). Two additional m / z 117 (21%) and 115 (12%) cleavage fragment ions from the ester group. Low abundance fragment peaks of m / z 375 (2%) and 331 (2%) are also important from ions containing 4-nitrophenyl. This result provides a rapid identification and pharmacological study of cilnidipine Important experimental basis.