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S-100蛋白因其高度的敏感性而作为诊断黑色素瘤和外周神经鞘膜肿瘤的金标准,但其可同时表达于多种间叶性肿瘤而特异性较低。Sox10是一种参与神经嵴细胞形成后期、神经嵴细胞作为干细胞的多潜能性维持和衍生细胞特异性分化为雪旺氏和黑色素细胞的神经嵴转录因子。作者应用组织芯
Because of its high sensitivity, S-100 protein is the gold standard for the diagnosis of melanoma and peripheral nerve sheath tumors, but it can be expressed in a variety of melanocytic tumors with low specificity. Sox10 is a neural crest transcription factor that participates in neural crest cell formation later in neural crest cells as pluripotent stem cell maintenance and derivative cell-specific differentiation into Schwann cells and melanocytes. The authors apply tissue cores