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目的 :探讨孕妇TORCH感染与胎儿畸形的关系 .方法 :采用酶联免疫吸附试验 (ELISA)法检测 10 0 0例孕妇血清TORCH的特异性抗体IgM ,对检测抗体阳性者和有畸胎史、不良孕产史的孕妇 ,用PCR法来检测TORCHDNA .结果 :孕妇TORCHIgM阳性率为 11.6 % ,其TOX ,RV ,HCMV ,HSVIgM阳性率分别为 3.6 0 % ,2 .5 0 % ,3.4 0 % ,2 .10 % ;母婴垂直传播率为 33.33% ,其中TOX ,RV ,HCMV ,HSV的垂直传播率分别为 4 3.33% ,2 6 .32 % ,34.6 2 % ,18.18% ;孕妇妊娠期间有上感症状者感染TORCHIgM阳性率 2 1.5 1%显著高于无上感症状者 9.34% (P <0 .0 1) ;有畸胎史TORCHIgM阳性率4 2 .10 %、不良孕产史 2 5 .4 0 % ,显著高于正常妊娠者 8.13% (P<0 .0 1) ;TORCH感染孕妇其胎儿畸形率 12 .37%显著高于无感染组 1.0 7% (P <0 .0 1) .结论 :孕妇TORCH感染是导致胎儿畸形的重要因素 .
Objective: To investigate the relationship between TORCH infection and fetal malformations in pregnant women.Methods: Serum TORCH-specific IgM was detected by enzyme-linked immunosorbent assay (ELISA) in 100 pregnant women with positive or negative teratogenicity The positive rates of TORCHIgM in pregnant women were 11.6%, and the positive rates of TOX, RV, HCMV and HSVIgM were 3.6%, 2.5%, 3.4%, 2 .10%. The vertical transmission rate of mother to child was 33.33%. The vertical transmission rates of TOX, RV, HCMV and HSV were 4.33%, 26.32%, 34.62% and 18.18% respectively. Symptoms were infected TORCHIgM positive rate of 21.51% was significantly higher than those without symptoms of supraspinatus 9.34% (P <0.01); with a history of teratogenic TORCHIgM positive rate of 42.10%, history of adverse pregnancy 2.54 0%, which was significantly higher than that of normal pregnancy (8.13%, P <0.01). The fetal malformation rate in TORCH-infected pregnant women was significantly higher than that in non-infected patients (1.07%, 12.37%, P <0.01). : TORCH infection in pregnant women is an important factor in fetal malformations.