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目的 探索新生儿缺氧缺血性脑病 (HIE)的新的安全有效的治疗方法。方法 在对症、支持治疗的基础上加用生脉注射液 10～ 2 0mL静注或稀释后静滴 ,每日 1次。首次应用在入院后 1h内 ,不经稀释 ,7d为 1个疗程 ,重症可用至 2～ 3个疗程。结果 治疗组中度和重度患儿显效率明显高于对照组 ,预后不良率明显低于对照组 (P <0 0 5 ) ,临床症状持续时间较对照组缩短 (P <0 0 5 ) ,具有显著性差异。结论 早期足量地使用生脉注射液 ,具有保护窒息后脑损伤的作用 ,能有效阻断HIE的发生发展 ,防治缺氧缺血性心肌损害 ,减轻神经系统症状 ,缩短病程 ,降低患儿死亡率、致残率 ,提高生存质量。
Objective To explore a new safe and effective treatment for neonatal hypoxic-ischemic encephalopathy (HIE). Methods In the symptomatic, supportive treatment based on the use of Shengmai injection 10 ~ 20mL intravenous or intravenous dilution, once daily. The first application within 1h after admission, without dilution, 7d for a course of treatment, severe use available to 2 to 3 courses. Results The effective rate of moderate and severe children in the treatment group was significantly higher than that in the control group, the rate of poor prognosis was significantly lower than that in the control group (P <0.05), and the duration of clinical symptoms was shorter than that in the control group (P <0.05) Significant difference. Conclusions Early use of Shengmai Injection in adequate quantities can protect brain from injury after asphyxiation, effectively blocking the occurrence and development of HIE, preventing and treating hypoxic-ischemic myocardial damage, reducing nervous system symptoms, shortening the course of disease and decreasing the mortality of children , Disability rate, improve the quality of life.