论文部分内容阅读
目的回顾性分析我院SICU于2002年1月～2007年12月期间接受过高容量血液滤过(HVHF)治疗的感染性休克患者在ICU的生存状况,评价早期HVHF对感染性休克的治疗作用。方法收集并整理患者的临床资料,包括患者在被诊断为感染性休克当天的APACHE-Ⅱ评分、SOFA评分、血清Cr水平以及住SICU期间的病死率。在被诊断为感染性休克的48小时内开始HVHF者为早期HVHF组,48小时后开始HVHF者为晚期HVHF组。比较两组在诊断为感染性休克当天的APACHE-Ⅱ评分、SOFA评分、血清Cr水平以及住SICU期间的病死率。结果68例感染性休克患者接受了HVHF治疗,早期HVHF组和晚期HVHF组的ICU病死率分别为40.0%(14/35)和63.6%(21/33)。在被诊断为感染性休克的当天,两组之间的APACHE-Ⅱ评分、SOFA评分和血Cr水平无明显差别(均P>0.05),早期HVHF组的ICU病死率显著低于晚期HVHF组(P<0.05)。结论早期HVHF降低了感染性休克患者的ICU病死率。
Objective To retrospectively analyze the survival status of ICU in patients with septic shock treated with high volume hemofiltration (HVHF) in our hospital from January 2002 to December 2007 and to evaluate the therapeutic effect of early HVHF on septic shock . Methods Clinical data were collected and collated, including APACHE-II score, SOFA score, serum Cr level, and mortality during the SICU episode on the day the patient was diagnosed as having septic shock. Those who started HVHF within 48 hours of being diagnosed as septic shock were in the early HVHF group, those who started HVHF 48 hours later were in the late HVHF group. APACHE-II scores, SOFA scores, serum Cr levels, and mortality during SICU were compared between the two groups on the day of septic shock. Results Sixty-eight patients with septic shock were treated with HVHF. The mortality rates of ICU in early HVHF group and late HVHF group were 40.0% (14/35) and 63.6% (21/33), respectively. On the day of being diagnosed as septic shock, APACHE-Ⅱ score, SOFA score and blood Cr level had no significant difference between the two groups (all P> 0.05). The mortality rate of ICU in the early HVHF group was significantly lower than that in the late HVHF group P <0.05). Conclusion Early HVHF reduces the ICU mortality in patients with septic shock.