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Clarithromycin(CTM)和 Azithrom-ycin(ATM)是由 FDA 批准上市的口服制剂。化学与作用机理 CTM 和 ATM 都是新大环内酯类抗生素,其结构类似于红霉素,所不同的是,CTM 是内酯环6位的羟基被甲基化,ATM 是内酯环中加入一个 N 原子成为十五环。其作用机理也类似于红霉素,通过抑制细菌蛋白质的合成而起作用。抗菌谱与红霉素比较,CTM 对金葡菌、链球菌、嗜肺军团菌、Maraxella ca-tarrhalis、砂眼衣原体、溶脲枝原体和鸟分枝杆菌复合体(MAC)的活性增强,并与代谢产物有协同作用,并增强对流感嗜血菌的
Clarithromycin (CTM) and Azithrom-ycin (ATM) are oral preparations approved by the FDA. Chemistry and Mechanism Both CTM and ATM are neo-macrolide antibiotics and have a structure similar to that of erythromycin except that CTM is methylated at the 6-position of the lactone ring and ATM is a lactone ring Join a N atom into a fifteen ring. Its mechanism of action is also similar to that of erythromycin, which works by inhibiting the synthesis of bacterial proteins. Antibacterial spectrum Enhanced CTM activity against S. aureus, Streptococcus, Legionella pneumophila, Maraxella ca-tarrhalis, Chlamydia trachomatis, Mycoplasma viuritum and Mycobacterium avium complex compared to antibiotic spectrum with erythromycin Synergistic effect with metabolites, and enhance the hemolytic against influenza