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目的比较胰岛素不同给药方式治疗糖尿病酮症酸中毒的临床疗效。方法选取2006年7月—2013年10月的112例糖尿病酮症酸中毒患者为研究对象,将其按照随机数字法分为A组和B组,A组56例患者采取静脉持续滴注胰岛素治疗,B组56例患者采取微量泵皮下持续注射胰岛素治疗,观察二组的临床治疗效果。结果二组数据比较,A组患者血糖达标时间、尿酮体转阴时间、血酮体转阴时间和胰岛素用量均明显的高于B组(P<0.05),差异有统计学意义。A组和B组治疗前血糖、CO2CP、钾、钠、肌酐、尿素氮比较无明显的变化,差异无统计学意义(P>0.05);治疗后A组和B组血糖、CO2CP、钾、钠、肌酐、尿素氮均较治疗前有明显的改善,且组间的数据比较差异有统计学意义(P<0.05)。A组低血糖发生率为7.1%,B组低血糖发生率为0,A组低血糖发生率明显的高于B组(P<0.05),差异有统计学意义。结论与静脉持续滴注胰岛素法比较,微量泵皮下持续注射法治疗糖尿病酮症酸中毒更具优越性,降低相关并发症发生,且治疗安全性更高,值得临床中应用与推广。
Objective To compare the clinical effects of different administration of insulin on diabetic ketoacidosis. Methods A total of 112 patients with diabetic ketoacidosis from July 2006 to October 2013 were selected and divided into groups A and B according to the random number method. In group A, 56 patients were treated with intravenous infusion of insulin In group B, 56 patients underwent sustained subcutaneous injection of insulin for insulin treatment, and the clinical effects of the two groups were observed. Results The data of two groups were significantly higher than those in group B (P <0.05). The difference was statistically significant. There were no significant differences in blood glucose, CO2CP, potassium, sodium, creatinine and urea nitrogen between groups A and B before treatment (P> 0.05). After treatment, the blood glucose, CO2CP, , Creatinine and urea nitrogen were significantly improved compared with before treatment, and there was significant difference between the two groups (P <0.05). The incidence of hypoglycemia in group A was 7.1%, the incidence of hypoglycemia in group B was 0, and the incidence of hypoglycemia in group A was significantly higher than that in group B (P <0.05). The difference was statistically significant. Conclusion Compared with continuous infusion of insulin intravenous drip method, continuous injection of subcutaneous pump subcutaneous treatment of diabetic ketoacidosis have more advantages, reduce the incidence of complications, and the treatment of higher safety, it is worthy of clinical application and promotion.