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目的观察盆炎方联合腹腔镜手术治疗输卵管性不孕症的临床疗效。方法将60例输卵管性不孕症患者随机分为对照组和治疗组,每组30例。对照组行腹腔镜手术加输卵管通液术,治疗组在手术基础上加服盆炎方。两组总疗程均为3个月,1年后随访,观察宫内妊娠率、输卵管通畅率,比较血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、人细胞间黏附分子-1(ICAM-1)水平的变化情况。结果 1疗程结束1年后,治疗组、对照组宫内妊娠例数分别为19例、10例,组间宫内妊娠率比较,差异有统计学意义,治疗组明显高于对照组(P<0.05)。2组间治疗后比较,输卵管通畅率差异有统计学意义,治疗组明显高于对照组(P<0.05)。3治疗前后组内比较,两组血清IL-6、TNF-α、ICAM-1水平差异均有统计学意义(P<0.05);组间治疗后比较,血清IL-6、TNF-α、ICAM-1水平差异有统计学意义(P<0.05)。结论盆炎方联合腹腔镜手术治疗输卵管性不孕症的疗效满意,其机制可能与调节血清IL-6、TNF-α、ICAM-1等炎症因子的表达有关。
Objective To observe the curative effect of pelvic inflammatory disease combined with laparoscopy in the treatment of tubal infertility. Methods Sixty cases of tubal infertility were randomly divided into control group and treatment group, 30 cases in each group. The control group received laparoscopic surgery plus tubal fluid, the treatment group on the basis of surgery plus pot Yan prescription. The total duration of treatment was 3 months and followed up one year later. The intrauterine pregnancy rate and tubal patency rate were observed. The levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) Adhesion molecule-1 (ICAM-1) level changes. Results 1 year after the end of treatment, the number of intrauterine pregnancy in treatment group and control group were 19 cases and 10 cases respectively. The intrauterine pregnancy rate was significantly different between the two groups (P < 0.05). The difference of tubal patency rate between the two groups after treatment was statistically significant, the treatment group was significantly higher than the control group (P <0.05). The levels of IL-6, TNF-α and ICAM-1 in the two groups were significantly different before and after treatment (P <0.05). After treatment, the levels of IL-6, TNF- -1 level difference was statistically significant (P <0.05). Conclusions Panyanfang combined with laparoscopic operation is effective in treating tubal infertility. The mechanism may be related to the regulation of the expression of IL-6, TNF-α, ICAM-1 and other inflammatory factors.