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目的探讨胱抑素C(CysC)、C反应蛋白(CRP)及尿微量白蛋白(UMA)联合检测在糖尿病肾损伤诊断中的意义。方法选取96例2型糖尿病(T2DM)患者分为两组,其中糖尿病未发生肾脏病变即单纯糖尿病(SDM)组54例,糖尿病肾病(DN)组42例,另设对照组为48例健康体检者。利用全自动生化分析仪检测其静脉血中CysC、CRP及尿中UMA含量,并常规检测肌酐(CRE)的含量做为对照分析。结果 SDM组CysC、CRP、UMA与正常对照组比较差异有统计学意义(P<0.05),而CRE与正常对照组比较差异无统计学意义(P>0.05);DN组CysC、CRP、UMA与正常对照组及SDM组比较差异有统计学意义(P<0.05)。SDM组CysC、CRP、UMA三者联合检测阳性率为91%,显著高于单项检测(P<0.05)。结论 CysC、CRP、UMA是糖尿病早期肾损伤的敏感指标,监测患者三项指标的动态变化,可以早期发现糖尿病肾损伤,为临床诊治提供依据。
Objective To investigate the significance of combined detection of cystatin C (CysC), C-reactive protein (CRP) and urinary microalbumin (UMA) in the diagnosis of diabetic nephropathy. Methods Sixty-six patients with type 2 diabetes mellitus (T2DM) were divided into two groups. Among them, there were 54 cases of diabetic nephropathy, 42 cases of diabetic nephropathy (DN) and 48 cases of healthy control By. The contents of CysC, CRP and urine UMA in venous blood were detected by automatic biochemical analyzer. The content of creatinine (CRE) was routinely measured as a control. Results There were significant differences in CysC, CRP and UMA between the SDM group and the normal control group (P <0.05), but there was no significant difference between CRE and normal control group (P> 0.05) There was significant difference between normal control group and SDM group (P <0.05). The positive rate of CysC, CRP and UMA in SDM group was 91%, which was significantly higher than that of single test (P <0.05). Conclusions CysC, CRP and UMA are sensitive indicators of early renal injury in diabetic patients. Monitoring the dynamic changes of three indicators in patients can detect diabetic renal injury early and provide the basis for clinical diagnosis and treatment.