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目的探讨氨溴索联合小剂量肝素雾化吸入治疗重症肺炎患儿的临床疗效。方法选取2015年3月-2016年3月在东莞市厚街医院儿科收治的重症肺炎患儿82例,随机分为观察组和对照组,每组41例,对照组的患儿采取常规的治疗方法,观察组的患者在对照组的基础上给予氨溴索联合小剂量肝素雾化吸入进行治疗。比较两组患儿的治疗总有效率、临床体征平均消失时间(三凹征、鼻翼煽动、气促、紫绀、肺部啰音),比较两组患儿的不良反应发生率。结果观察组患儿的临床治疗总有效率显著高于对照组(P<0.05),观察组患儿的平均临床体征消失时间显著短于对照组(P<0.05),观察组患儿与对照组患儿的不良反应发生率差异无统计学意义(P>0.05)。结论氨溴索联合小剂量肝素雾化治疗重症肺炎患儿临床效果显著,能够促进患儿临床症状的消失,并且安全可靠,值得推广应用。
Objective To investigate the clinical efficacy of ambroxol combined with low-dose heparin atomized inhalation in children with severe pneumonia. Methods From March 2015 to March 2016, 82 children with severe pneumonia admitted to Houjie Hospital of Dongguan City were randomly divided into observation group and control group, 41 cases in each group. The control group received routine treatment Methods: Patients in the observation group were treated with inhalation of ambroxol and low-dose heparin inhalation on the basis of the control group. The total effective rate of treatment, the average disappearance time of clinical signs (trigeminal tract, nasal flaring, shortness of breath, cyanosis, pulmonary rales) in both groups were compared. The incidence of adverse reactions in both groups was compared. Results The total effective rate of clinical treatment in observation group was significantly higher than that in control group (P <0.05). The mean disappearance time of clinical signs in observation group was significantly shorter than that in control group (P <0.05) The incidence of adverse reactions in children with no significant difference (P> 0.05). Conclusion Ambroxol combined with low-dose heparin atomization in children with severe pneumonia has significant clinical effect, which can promote the disappearance of clinical symptoms in children and is safe and reliable. It is worth popularizing and applying.