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应用免疫组化Ｓ－Ｐ法检测了１１１例大肠癌及５７例癌旁粘膜组织的Ｃ－ｅｒｂＢ－２癌基因蛋白和ＰＣＮＡ表达状况。结果表明：①大肠癌组织Ｃ－ｅｒｂＢ－２癌基因蛋白和ＰＣＮＡ阳性表达率分别为４８．６％，７２．１％；癌旁粘膜仅为２８．１％，１４．８％；前者Ｃ－ｅｒｂＢ－２（Ｐ＜０．０５）ｆｏＰＣＮＡ（Ｐ＜０．０１）的表达率显著高于后者。②Ｃ－ｅｒｂＢ－２癌基因蛋白和ＰＣＮＡ阳性率与癌组织分化程度及淋巴结转移有显著相关性（Ｐ＜０．０５）。提示：测定Ｃ－ｅｒｂＢ－２癌基因产物和ＰＣＮＡ，有助于对大肠癌生物学行为的进一步认识及患者预后的分析。
Immunohistochemical S-P method was used to detect C-erbB-2 oncogene protein and PCNA expression in 111 cases of colorectal cancer and 57 cases of adjacent mucosa. The results showed that: 1 The positive rates of C-erbB-2 oncogene protein and PCNA in colorectal cancer tissues were 48.6% and 72.1%, respectively, and those in adjacent mucosa were only 28.1% and 14.8%. The former was C- The expression rate of erbB-2 (P<0.05)foPCNA (P<0.01) was significantly higher than that of the latter. 2 The positive rate of C-erbB-2 oncogene protein and PCNA was significantly correlated with the degree of differentiation and lymph node metastasis (P<0.05). Tip: Determination of C-erbB-2 oncogene product and PCNA can help to further understand the biological behavior of colorectal cancer and analyze the prognosis of patients.