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目的探讨血清S100β蛋白及IL-10含量预测急性脑出血患者迟发性脑水肿的临床意义。方法选择我院2015年7月到2016年2月收治的并发迟发性脑水肿的急性脑出血患者36例作为观察组,选择同期非迟发性脑水肿的急性脑出血患者64例作为对照组。对两组患者入院后第1、7、14、21、28天进行头颅MRI检查,观察脑出血量及血肿周围水肿量;测定比较两组患者在第1、7、14、21、28天的血清S100β蛋白、IL-10含量。结果观察组第1、7、14、21、28天的脑出血量、脑水肿量、血清S100β蛋白、IL-10含量均明显高于对照组(P<0.05)。结论急性脑出血患者的血清S100β蛋白及IL-10含量可以有效地预测迟发性脑水肿,与脑颅MRI相结合,对预防急性脑出血患者并发迟发性脑水肿具有很高的临床意义。
Objective To investigate the clinical significance of serum S100β protein and IL-10 in predicting delayed cerebral edema in patients with acute cerebral hemorrhage. Methods Thirty-six patients with acute cerebral hemorrhage complicated with delayed-onset cerebral edema in our hospital from July 2015 to February 2016 were selected as the observation group. Sixty-four patients with acute cerebral hemorrhage in the same period of non-delayed cerebral edema were selected as the control group . On the first, seventh, fourteenth, twelfth, and twenty-eighth day after admission, the cranial MRI was performed to observe the amount of cerebral hemorrhage and the amount of edema around the hematoma. The two groups were compared on days 1,7,14,21,28 Serum S100β protein, IL-10 content. Results On the 1st, 7th, 14th, 21st and 28th day in observation group, the amounts of cerebral hemorrhage, brain edema, S100β protein and IL-10 in serum in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Serum levels of S100β and IL-10 in patients with acute intracerebral hemorrhage can effectively predict delayed cerebral edema. Combining with brain MRI, it is of great clinical significance in the prevention of delayed cerebral edema in patients with acute cerebral hemorrhage.