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目的:探讨临沂市沂水中心医院药品不良反应(ADR)的发生特点,为临床合理用药提供科学依据。方法收集我院2014年1月至2014年8月上报的305例药品不良反应报告,从患者年龄、性别、药品种类、药品剂型、给药途径、临床表现、转归等方面进行统计学分析。结果 41~60岁年龄组患者发生ADR最多(占39.67%),抗菌药物引起的ADR最多(占45.57%);静脉注射是引起ADR的主要给药途径(占93.44%);临床表现以皮肤瘙痒、皮疹为主(占46.23%),大部分患者ADR好转,无后遗症。结论加强ADR监测,掌握其发生特点,能减少ADR的发生率,促进合理用药,是保证安全用药的有效措施。
Objective: To investigate the occurrence of adverse drug reaction (ADR) in Yishui Central Hospital of Linyi and provide a scientific basis for clinical rational drug use. Methods A total of 305 adverse drug reactions reported in our hospital from January 2014 to August 2014 were collected and analyzed statistically in terms of patient’s age, gender, type of drug, dosage form, route of administration, clinical manifestation and prognosis. Results The highest ADR (39.67%) occurred in 41-60 age group and the highest ADR (45.57%) caused by antibiotics. The main route of administration of ADR caused by intravenous injection (93.44%) was intravenous injection. The clinical manifestations were pruritus , Rash (46.23%), ADR improved in most patients, no sequelae. Conclusion To strengthen the monitoring of ADR and grasp the characteristics of ADR can reduce the incidence of ADR and promote the rational use of drugs, which is an effective measure to ensure safe medication.