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目的评估术中射频消融治疗不能切除胰腺癌病例的有效性和安全性。方法对23例不能切除的胰腺癌病例实施术中射频消融,观察患者手术前后疼痛、黄疸、CA19-9、CEA、淀粉酶、影像学改变及术后并发症和生存率。结果术后87.05%的患者腹痛缓解,92%黄疸消退,CA19-9、CEA明显下降,淀粉酶一过性增高,术后CT示病灶血供减少。并发出血6例,胰瘘6例,均治愈出院。所有患者均获得随访,存活12个月以上12例,最长者已达42个月,生活质量较好。结论术中射频消融治疗不能切除的胰腺癌安全有效。
Objective To evaluate the effectiveness and safety of intraoperative radiofrequency ablation in patients with unresectable pancreatic cancer. Methods Twenty-three patients with unresectable pancreatic cancer underwent radiofrequency ablation. The pain, jaundice, CA19-9, CEA, amylase, imaging changes and postoperative complications and survival rate were observed before and after operation. Results Postoperative 87.05% of patients had relieved abdominal pain, 92% jaundice regressed, CA19-9, CEA decreased significantly, amylase increased transiently, postoperative CT showed focal lesion blood supply decreased. Hemorrhage occurred in 6 cases, 6 cases of pancreatic fistula were cured. All patients were followed up, 12 cases survived more than 12 cases, the longest 42 months, better quality of life. Conclusions Intraoperative radiofrequency ablation is safe and effective in the treatment of unresectable pancreatic cancer.