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[Objective]To solve the severe precipitation of Tongnao oral solution and evaluate its pharmacodynamic effects.[Methods]The main components of Tongnao oral solution,including Red Ginseng,Notoginseng,Chuanxiong,Rhubarb and Leech,were extracted respectively for pair combination testing. Clotting time of normal mice and ischemic mice was employed as the indicator for evaluating the pharmacodynamics of final products.[Results]The pair combination testing showed that tannin in rhubarb would act on some components of other medicinal herbs and produce precipitation. After tannin was removed by using improved gelatin method,the Tongnao oral solution was clear and stable, and it could remarkably elongate the clotting time of normal mice and ischemic mice.[Conclusion]This technique can well solve the severe precipitation of Tongnao oral solution and ensure the effectiveness of the products.
[Objective] To solve the severe precipitation of Tongnao oral solution and evaluate its pharmacodynamic effects. [Methods] The main components of Tongnao oral solution, including Red Ginseng, Notoginseng, Chuanxiong, Rhubarb and Leech, were extracted respectively for combination testing. time of normal mice and ischemic mice was employed as the indicator for evaluating the pharmacodynamics of final products. [Results] The pair combination testing showed that tannin in rhubarb would act on some components of other medicinal herbs and produce precipitation. After tannin was removed by using improved gelatin method, the Tongnao oral solution was clear and stable, and it could remarkably elongate the clotting time of normal mice and ischemic mice. [Conclusion] This technique can well solve the severe precipitation of Tongnao oral solution and ensure the effectiveness of the products.