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为了阐明矽酸在矽肺发病过程中的作用,须首先肯定矽酸的致纤维化作用。早在1922年,Gye 已由动物实验证实了胶体矽酸对机体具有毒性作用,并指出单体矽酸只有急性中毒作用,而聚合体矽酸才有致纤维化的性能。之后,其他学者也进行了这方面的研究,但未取得一致的实验结果,1951年发表了用矽酸经气管注入大白鼠后成功地获得实验性矽肺的报导。但是,其他一些学者对矽酸的致纤维化作用仍有争论。
In order to clarify the role of silicic acid in the pathogenesis of silicosis, we must first confirm the silicic acid induced fibrosis. As early as 1922, Gye has been confirmed by animal experiments that colloidal silicic acid has a toxic effect on the body, and pointed out that the monomeric silicic acid has only an acute poisoning effect, and the polymeric silicic acid has fibrinolytic properties. Later, other scholars also conducted this research, but did not get consistent experimental results, published in 1951 with silicic acid tracheal injection of rats successfully obtained experimental silicosis reported. However, some other scholars on the role of silicic acid fibrosis still controversial.