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维生素K2(VK2)是一种有效的肿瘤诱导剂,体内外实验证明,VK2能诱导多种血液肿瘤细胞株及原代培养的白血病细胞、骨髓异常增生细胞发生凋亡,并且当凋亡受到抑制时,能诱导细胞向单核细胞分化。它的作用机制与多种因素如细胞内特异性受体、癌基因的表达、氧自由基产生增多、细胞内谷胱甘肽耗竭及促使蛋白巯基芳香化有关。VK2已用于骨髓异常增生综合征、急性髓性白血病患者的临床治疗,并取得了很好的疗效。VK2临床应用的安全性及低毒性副作用在临床观察中得到证实。
Vitamin K2 (VK2) is a potent tumor inducer. VK2 has been shown to induce apoptosis in a variety of hematological tumor cell lines and primary cultured leukemic cells, myeloid dysplastic cells in vitro and in vivo When, can induce cells to monocytes differentiation. Its mechanism of action and a variety of factors such as intracellular specific receptors, oncogene expression, increased production of oxygen free radicals, depletion of intracellular glutathione and promote protein sulfhydryl aromatisation. VK2 has been used in the clinical treatment of patients with myelodysplastic syndrome and acute myeloid leukemia, and has achieved good results. VK2 clinical application of safety and low toxicity side effects confirmed in clinical observations.