母体血清和体外受精胚胎培养液中的肿瘤坏死因子

• 作 者: 蔡春友
• 出 处: 国外医学.妇产科学分册
• 发表日期: 1991年06期
• 关键词: 体外受精 胚胎培养液 母体血清 肿瘤坏死因子 成熟滤泡 单核巨噬细胞 胚胎种植 前列腺素 组织损伤 检测水平

肿瘤坏死因子(TNF)可增强炎症,激活巨噬细胞,刺激前列腺素的产生,也与组织损伤有关。据此推测TNF有可能促进同种异体胎儿的排斥。在分娩妇女的羊水中已发现有TNF,推测其可能刺激分娩。TNF除了由单核巨噬细胞产生外,也可由卵巢局部产生,并可能为成熟滤泡破裂所必需。行体外受精(IV F)的妇女,由于应用激素可诱发多个滤泡同时成熟,以导致TNF在循环中达到可检测水平。

Tumor necrosis factor (TNF) increases inflammation, activates macrophages, stimulates the production of prostaglandins, and is also associated with tissue damage. This suggests that TNF may promote the rejection of allogeneic fetuses. TNF has been found in the amniotic fluid of childbirth women, suggesting that it may stimulate childbirth. In addition to being produced by mononuclear macrophages, TNF may also be produced locally by the ovary and may be necessary for the rupture of mature follicles. In IVF women, multiple follicles are induced to mature at the same time by the use of hormones, resulting in TNF reaching detectable levels in the circulation.