参芪地黄汤治疗糖尿病肾病的网络药理学机制

来源 :湖北民族大学学报:医学版 | 被引量 : 0次 | 上传用户：luosenkate

【摘要】

：

目的通过采用网络药理学方法,探讨参芪地黄汤治疗糖尿病肾病(DN)的作用机制.方法利用TCMSP数据库平台查找参芪地黄汤的有效化学成分及与化学成分相关的潜在靶点,并在UniProt数据库中对靶点的名称标准化.再利用Gene Cards数据库、OMIM数据库筛选出与DN相关的疾病靶点,并通过Cytoscape 3.7.2软件构建成分-靶点-基因-疾病之间相互作用的网络关系图,进而在STRING数据库中绘制蛋白-蛋白PPI网络图,采用Rx643.6.2软件及Bioconductor生物信息软件包对药物与疾病的交

【作者】

：

吴健付彤飞袁军

【机构】

：

湖北中医药大学,湖北省中医院,湖北省中医药研究院

【出处】

：

湖北民族大学学报:医学版

【发表日期】

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2021年3期

【关键词】

：

参芪地黄汤糖尿病肾病网络药理学信号通路

【基金项目】

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国家自然科学基金项目(82074364),湖北省自然科学基金项目(2019CFB619),湖北省卫生健康委科研项目(WJ2021M180)。

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