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选择2014年1月~2015年9月老年2型糖尿病患者136例为研究对象进行回顾性资料分析,按照是否发生严重低血糖将其分为非低血糖组(102例)和低血糖组(34例),采用logistic多因素分析危险因素。结果低血糖组和非低血糖组住院时间、体重指数及病程比较差异均有统计学意义(P<0.05);低血糖组二甲双胍使用比例明显低于非低血糖组(P<0.05),心脑血管疾病药物联用比例、胰岛素及口服降糖药与胰岛素的联合使用比例明显高于非低血糖组(P<0.05);低血糖组低血钾症发生率和肾功能相关指标明显高于非低血糖组(P<0.05),低血糖组中性粒细胞和白细胞明显高于非低血糖组(P<0.05)。logistic多因素分析表明病程>10年、果糖胺<2.5mmol/L、使用胰岛素及胰岛素与口服降糖药联用、肾功能受损、白细胞升高均与严重低血糖相关。结论治疗老年2型糖尿病行降糖治疗时应认真评估上述各危险因素,以避免老年2型糖尿病患者发生严重低血糖。
A total of 136 elderly patients with type 2 diabetes mellitus from January 2014 to September 2015 were retrospectively analyzed, and were divided into non-hypoglycemia group (n = 102) and hypoglycemia group Cases), using logistic multivariate analysis of risk factors. Results The duration of hospital stay, body mass index and course of disease in hypoglycemia group and non-hypoglycemia group were significantly different (P <0.05). The use of metformin in hypoglycemia group was significantly lower than that in non-hypoglycemia group (P <0.05) The combined use of drugs for vascular diseases, the combined use of insulin and oral hypoglycemic agents and insulin was significantly higher than that of non-hypoglycemia groups (P <0.05), and the incidence of hypokalemia and renal function in hypoglycemia group were significantly higher than those in non-hypoglycemia group Hypoglycemia group (P <0.05), neutrophils and leukocytes in hypoglycemia group were significantly higher than those in non-hypoglycemia group (P <0.05). Logistic multivariate analysis showed that duration of disease> 10 years, fructosamine <2.5mmol / L, the use of insulin and insulin combined with oral hypoglycemic agents, impaired renal function, leukocytosis are associated with severe hypoglycemia. Conclusions The above risk factors should be carefully evaluated in the treatment of type 2 diabetes in elderly patients with hypoglycemic treatment to avoid serious hypoglycemia in elderly type 2 diabetic patients.